gpkpdsim application Search Results


gpkpdsim application  (MathWorks Inc)
90
MathWorks Inc gpkpdsim application
Gpkpdsim Application, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/gpkpdsim application/product/MathWorks Inc
Average 90 stars, based on 1 article reviews
gpkpdsim application - by Bioz Stars, 2026-03
90/100 stars
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gpkpdsim  (Genentech inc)
90
Genentech inc gpkpdsim
A schematic workflow of how modelers and end-users employ <t>gPKPDSim.</t> The expert modeler develops the model in SimBiology ® and encapsulates it into a “Session” file, which can be launched in gPKPDSim by end-users. The Session file, once loaded in gPKPDSim, enables the end-user to perform different functionalities, including simulation, data fitting (parameter estimation), population simulation, and NCA. For some of these functionalities, the user must provide a dataset. All the functionalities are supported by features such as interactive visualization, and export of results as presentation-ready figures and Excel datasets. When the user completed their tasks, the session file can be saved for future use. Note that the end-user works exclusively in the environment of gPKPDSim
Gpkpdsim, supplied by Genentech inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/gpkpdsim/product/Genentech inc
Average 90 stars, based on 1 article reviews
gpkpdsim - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier

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A schematic workflow of how modelers and end-users employ gPKPDSim. The expert modeler develops the model in SimBiology ® and encapsulates it into a “Session” file, which can be launched in gPKPDSim by end-users. The Session file, once loaded in gPKPDSim, enables the end-user to perform different functionalities, including simulation, data fitting (parameter estimation), population simulation, and NCA. For some of these functionalities, the user must provide a dataset. All the functionalities are supported by features such as interactive visualization, and export of results as presentation-ready figures and Excel datasets. When the user completed their tasks, the session file can be saved for future use. Note that the end-user works exclusively in the environment of gPKPDSim

Journal: Journal of Pharmacokinetics and Pharmacodynamics

Article Title: gPKPDSim: a SimBiology ® -based GUI application for PKPD modeling in drug development

doi: 10.1007/s10928-017-9562-9

Figure Lengend Snippet: A schematic workflow of how modelers and end-users employ gPKPDSim. The expert modeler develops the model in SimBiology ® and encapsulates it into a “Session” file, which can be launched in gPKPDSim by end-users. The Session file, once loaded in gPKPDSim, enables the end-user to perform different functionalities, including simulation, data fitting (parameter estimation), population simulation, and NCA. For some of these functionalities, the user must provide a dataset. All the functionalities are supported by features such as interactive visualization, and export of results as presentation-ready figures and Excel datasets. When the user completed their tasks, the session file can be saved for future use. Note that the end-user works exclusively in the environment of gPKPDSim

Article Snippet: We have developed a GUI-based application called gPKPDSim (Genentech PKPD Simulator) to broaden utilization of preclinical and translational PKPD models in drug development.

Techniques:

Description of the components within the gPKPDSim framework

Journal: Journal of Pharmacokinetics and Pharmacodynamics

Article Title: gPKPDSim: a SimBiology ® -based GUI application for PKPD modeling in drug development

doi: 10.1007/s10928-017-9562-9

Figure Lengend Snippet: Description of the components within the gPKPDSim framework

Article Snippet: We have developed a GUI-based application called gPKPDSim (Genentech PKPD Simulator) to broaden utilization of preclinical and translational PKPD models in drug development.

Techniques: Generated

gPKPDSim: simulation functionality view. This view has multiple sections: 1 ) general settings (top left); 2 ) functionality-specific settings including simulation time and parameter values (bottom left); 3 ) plot settings including species from the SimBiology ® model and dataset groups and column headers (top right); 4 ) non-compartmental analysis (NCA, bottom right); 5 ) profile notes including a list of most recent simulations and their detailed summary (bottom middle); and 6 ) interactive plots (top middle). See “ ” for detailed description of each section

Journal: Journal of Pharmacokinetics and Pharmacodynamics

Article Title: gPKPDSim: a SimBiology ® -based GUI application for PKPD modeling in drug development

doi: 10.1007/s10928-017-9562-9

Figure Lengend Snippet: gPKPDSim: simulation functionality view. This view has multiple sections: 1 ) general settings (top left); 2 ) functionality-specific settings including simulation time and parameter values (bottom left); 3 ) plot settings including species from the SimBiology ® model and dataset groups and column headers (top right); 4 ) non-compartmental analysis (NCA, bottom right); 5 ) profile notes including a list of most recent simulations and their detailed summary (bottom middle); and 6 ) interactive plots (top middle). See “ ” for detailed description of each section

Article Snippet: We have developed a GUI-based application called gPKPDSim (Genentech PKPD Simulator) to broaden utilization of preclinical and translational PKPD models in drug development.

Techniques:

NCA results for the sparse sampling scheme from gPKPDSim and WinNonlin ® (two sets of NCA parameters corresponding to two groups)

Journal: Journal of Pharmacokinetics and Pharmacodynamics

Article Title: gPKPDSim: a SimBiology ® -based GUI application for PKPD modeling in drug development

doi: 10.1007/s10928-017-9562-9

Figure Lengend Snippet: NCA results for the sparse sampling scheme from gPKPDSim and WinNonlin ® (two sets of NCA parameters corresponding to two groups)

Article Snippet: We have developed a GUI-based application called gPKPDSim (Genentech PKPD Simulator) to broaden utilization of preclinical and translational PKPD models in drug development.

Techniques: Sampling

NCA results for the serial sampling scheme from gPKPDSim (two groups × three animals = six sets of NCA parameters)

Journal: Journal of Pharmacokinetics and Pharmacodynamics

Article Title: gPKPDSim: a SimBiology ® -based GUI application for PKPD modeling in drug development

doi: 10.1007/s10928-017-9562-9

Figure Lengend Snippet: NCA results for the serial sampling scheme from gPKPDSim (two groups × three animals = six sets of NCA parameters)

Article Snippet: We have developed a GUI-based application called gPKPDSim (Genentech PKPD Simulator) to broaden utilization of preclinical and translational PKPD models in drug development.

Techniques: Sampling

Estimated AUC values for the period of 0–28 days of a 10 mg/kg 4qw IV dosing regimen under different conditions (Fig. <xref ref-type= 4 c and e)" width="100%" height="100%">

Journal: Journal of Pharmacokinetics and Pharmacodynamics

Article Title: gPKPDSim: a SimBiology ® -based GUI application for PKPD modeling in drug development

doi: 10.1007/s10928-017-9562-9

Figure Lengend Snippet: Estimated AUC values for the period of 0–28 days of a 10 mg/kg 4qw IV dosing regimen under different conditions (Fig. 4 c and e)

Article Snippet: We have developed a GUI-based application called gPKPDSim (Genentech PKPD Simulator) to broaden utilization of preclinical and translational PKPD models in drug development.

Techniques:

gPKPDSim settings used for Case Study #2

Journal: Journal of Pharmacokinetics and Pharmacodynamics

Article Title: gPKPDSim: a SimBiology ® -based GUI application for PKPD modeling in drug development

doi: 10.1007/s10928-017-9562-9

Figure Lengend Snippet: gPKPDSim settings used for Case Study #2

Article Snippet: We have developed a GUI-based application called gPKPDSim (Genentech PKPD Simulator) to broaden utilization of preclinical and translational PKPD models in drug development.

Techniques:

gPKPDSim settings used for Case Study #3

Journal: Journal of Pharmacokinetics and Pharmacodynamics

Article Title: gPKPDSim: a SimBiology ® -based GUI application for PKPD modeling in drug development

doi: 10.1007/s10928-017-9562-9

Figure Lengend Snippet: gPKPDSim settings used for Case Study #3

Article Snippet: We have developed a GUI-based application called gPKPDSim (Genentech PKPD Simulator) to broaden utilization of preclinical and translational PKPD models in drug development.

Techniques: Inhibition